Luke Clarke

Functional Medicine Practitioner and Naturopath in Melbourne

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March 2, 2018 by Luke Leave a Comment

Popular Acid Reflux Meds May Promote Chronic Liver Disease

Approximately 10 percent of adults in Australia take proton pump inhibitor (PPI)Image result for proton pump inhibitors drugs to block stomach acid and relieve symptoms of frequent heartburn, acid reflux and gastroesophageal reflux disease (GERD). Significantly, people with chronic liver disease are seven times more likely to take PPI drugs.

In a new study published in Nature Communications, researchers at the University of California San Diego School of Medicine have discovered evidence that stomach (gastric) acid suppression alters specific gut bacteria in a way that promotes liver injury and increases progression of three types of chronic liver disease.

“Our stomachs produce gastric acid to kill ingested microbes, and taking a medication to suppress gastric acid secretion can change the composition of the gut microbiome.”

According to senior author Bernd Schnabl, MD, Since we found previously that the gut microbiome — the communities of bacteria and other microbes living there — can influence liver disease risk, we wondered what effect gastric acid suppression might have on the progression of chronic liver disease.

“We found that the absence of gastric acid promotes growth of Enterococcus bacteria in the intestines and translocation to the liver, where they exacerbate inflammation and worsen chronic liver disease.”

Liver cirrhosis is the 12th leading cause of death worldwide and the number of people with chronic liver disease is increasing rapidly in Western countries. The increase is partly due to the rising prevalence of obesity, which is associated with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Approximately half of all cirrhosis-associated deaths are related to alcohol.

PPIs, which include brand names such as Zantac, Nexium and Losec, are among the most commonly prescribed medications in the world, particularly among people with chronic liver disease. They are also relatively inexpensive medications, retailing for approximately $7 for a recommended two-week course.

 

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March 2, 2018 by Luke 1 Comment

Why South Korean women are living so long

They put it down to advanced healthcare systems, lower average-body-
mass indexes (BMIs) and, in South Korea, cabbage, lots of cabbage.

Women are, generally, living longer than men, particularly in South Korea, which is set to become the first nation with an average life expectancy above 90.Image result for kimchi

An article published on the World Economic Forum website, based on research first published in the Lancet journal, said women born in South Korea in 2030 are projected to be the first in the world with an average life expectancy of above 90.

It noted that France, Japan, Australia, Canada, Chile and the UK were not far behind – all were likely to see women’s average life expectancy at birth pass 85 by 2030.

The research was conducted by the Imperial College London and the World Health Organization, which looked at future life expectancy in 35 industrialised countries.

The researchers predicted that life spans would continue to increase significantly in most of the countries studied.

The US, however, bucked the trend somewhat – here life expectancy will rise more slowly, researchers say. This is due to factors like obesity, unequal access to healthcare and homicide rates.

But what are some of the secrets to the longevity of South Korean women?

One factor to be taken into account is how tall people are. The US, the WEF article noted, is the first wealthy country to experience stagnation or even a possible decline in average adult height – a factor that correlates closely with health and longevity.

“The study, which uses 21 different models to forecast life expectancy, gives South Korean women born in 2030 a 57% chance of exceeding the age of 90, and a 97% probability they will live to be over 86.”

It said South Koreans’ expected longevity is based on the assumption that they will have lower average-body-mass indexes (BMIs) and blood pressure than citizens of other comparable countries.

Kimchi, a hugely popular dish in South Korea, with widely heralded health benefits.

Then there is diet, and particularly its famous dish, Kimchi. Based on fermented vegetables – usually cabbage – it is high in probiotics and vitamins A and B.

Other factors that come into play are nutritional education, advances in economic and social status, lower road-traffic accident rates and high-quality healthcare systems, which improve prevention and survival rates from serious diseases and reduce infant mortality.

Nature.com said some of the reasons for the nation’s dramatic improvements since the 1980s were improved economic status and advances in child nutrition.

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January 18, 2018 by Luke Leave a Comment

Global Study Finds Higher Intake of Saturated-Fats Reduces Mortality

Related image

Results from a recently released, long awaited dietary study will put supporters of low-fat diets into a carbohydrate-fueled tailspin. According to the large cohort Prospective Urban Rural Epidemiology PURE study, higher fat diets that include both saturated and unsaturated fats are associated with a lower risk of mortality. And replacing said fats with high carbohydrate intakes (above 60% energy) is associated with higher risk mortality.

The news, presented in Barcelona at the European Cardiology Congress and published in Lancet, shows the world has a significant health problem: too many people consume too many simple carbohydrates and too few fats. Why? Many take advice from European and North American health advisories, which may not be relevant to moderate and low-income populations.

The study included people aged 35-70 years old from 18 countries across various regions including the Middle East, South America, Africa, China, North America and Europe, and South Asia and looked at the links between diet, cardiovascular disease and death. Participants’ completed follow-up visits with the researchers every three years to record information on cardiovascular disease (ie, fatal and non-fatal heart attacks, stroke and heart failure) and death for 7.4 years. The team analysed rates of cardiovascular events (for example, heart attack, stroke, heart failure), cardiovascular deaths and and non-cardiovascular deaths.

PURE Study Points to Fewer Carbs and Greater Fat Intake

The study found that on average, globally, people’s diets consisted of over 60% energy from carbohydrates and 24% energy from fats, suggesting that rather than focusing on reducing fat intake, dietary guidelines should instead focus on reducing carbohydrate consumption, particularly in low- and middle-income countries where carbohydrate intake was highest.

Additionally, while current guidelines recommend reducing saturated fat intake to below 10%, the study found that very low intake of saturated fats (below 3%) was associated with a higher risk of mortality, compared to diets with a higher intake of saturated fats of up to 13%.

“For the first time, our study provides a global look at the realities of people’s diets in many countries and gives a clearer picture of people’s fat and carbohydrate intake,” says lead author Dr. Mahshid Dehghan, McMaster University, Canada. “The current focus on promoting low-fat diets ignores the fact that most people’s diets in low and middle income countries are very high in carbohydrates, which seem to be linked to worse health outcomes. In low- and middle-income countries, where diets sometimes consist of more than 65% of energy from carbohydrates, guidelines should refocus their attention towards reducing carbohydrate intake, instead of focusing on reducing fats.”

The best diets will include a balance of carbohydrates and fats – approximately 50-55% carbohydrates and around 35% total fat, including both saturated and unsaturated fats. Our study did not look at trans fats, typically from processed foods, and the evidence is clear that these are unhealthy,” says Dehghan.

Critical Findings of PURE Study

Globally, the average diet consisted of 61.2% carbohydrates, 23.5% fat (including 8% saturated fats, 8.1% monounsaturated fats, and 5.3% polyunsaturated fats), and 15.2% protein.

However, this balance varied by region: on average, carbohydrate intake was highest in China (67%), South Asia (65.4%) and Africa (63.3%); total fat intake was highest in North America and Europe (30.5%), Middle East (30.3%), and Southeast Asia (29.2%).

High carbohydrate diets were common, with more than half of the people in the study eating a high carbohydrate diet (at least 60% of energy from carbohydrates), and about a quarter deriving 70% of their daily calories from carbohydrates.

Half of the people involved derived less than 7% of their energy from saturated fats, and three-quarters (75%) ate less than 10% from saturated fats.

Cardiovascular Disease Outcomes

During the study, 5,796 people died (including 1,649 from cardiovascular disease and 3,809 from non-cardiovascular disease) and 4,784 had a major cardiovascular disease event (2,143 heart attacks and 2,234 strokes).

Diets high in carbohydrates (average of 77% energy from carbohydrates) were associated with a 28% higher risk of death, compared with low carbohydrate diets (46% energy from carbohydrates). Rates of major cardiovascular events remained similar for low and high carbohydrate diets.

Comparatively, diets with high total fat intake (35.3% energy from fat) were associated with a 23% lower risk of death, compared with low fat diets (11.0% energy from fat).

Rates of major cardiovascular events remained similar for low and high fat diets.

The trends were similar when looking at saturated fats, with very low intake (below 3%) associated with a higher risk of mortality, compared to diets with a higher intake of saturated fats of up to 13%.

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January 18, 2018 by Luke Leave a Comment

Want to live to 100? Try being stubborn

Image result for living to 100

We are usually told the key to living to a ripe old age is a healthy diet and plenty of exercise.

But for those wanting to reach 100, it seems a sheer determination to carry on could also keep us alive.

Having a positive outlook, stubbornness and continuing to keep busy could be key to a long life, a study suggests.

Love of one’s family, a strong work ethic and religious faith were also factors.

Researchers studied 29 people aged between 91 and 101, who were unsurprisingly found to have worse physical health than their family members aged 51 to 75.

But when it came to mental health, the oldest inhabitants of nine villages in Cilento, southern Italy, were found to be in better shape than younger relatives, suggesting that advancing years lend a greater sense of well-being.

The study by the University of Rome and University of California San Diego also found high self-confidence and decision-making skills among the very old group.

Lead author Anna Scelzo said: “The group’s love of their land is a common theme and gives them a purpose in life. Most of them are still working in their homes and on the land. They think, ‘This is my life and I’m not going to give it up’. We also found that this group tended to be domineering, stubborn and needed a sense of control, which can be a desirable trait as they are true to their convictions and care less about what others think.

“This tendency to control the environment suggests notable grit that is balanced by a need to adapt to changing circumstances.”

The researchers assessed mental and physical health, and also let the participants tell their life stories. Topics included traumatic events, migration and their beliefs.

Among those interviewed was a long-living man who had lost his wife of 70 years and had been left feeling empty after her loss a month before. He said: “Thanks to my sons, I am now recovering and feeling much better. I have four children, ten grandchildren and nine great-grandchildren. I have fought all my life and I am always ready for changes.

“I think changes bring life and give chances to grow.”

One nonagenarian said: “I am always thinking for the best. There is always a solution in life. This is what my father taught me – always face difficulties and hope for the best.”

Another quoted in the study, published in International Psychogeriatrics, said: “I am always active. I do not know what stress is. Life is what it is and must be faced always.”

One participant said: “I feel younger now than when I was young.”

Dr Dilip Jeste, professor of psychiatry at UCSD, said: “There have been a number of studies on very old adults, but they have mostly focused on genetics rather than their mental health or personalities.

“The main themes that emerged from our study, and appear to be the unique features associated with better mental health of this rural population, were positivity, work ethic, stubbornness and a strong bond with family, religion and land.”

Jeste added: “This paradox of ageing supports the notion that well-being and wisdom increase with ageing even though physical health is failing.

“Studying the strategies of exceptionally long-lived and lived-well individuals, who not just survive but also thrive and flourish, enhances our understanding of health and functional capacities in all age groups.”

A previous study looked at the diet and lifestyle of residents in Acciaroli, south-west Italy, where one in 10 locals lives past the age of 100. It found many elderly locals continued to enjoy an active sex life and a healthy Mediterranean diet featuring olive oil, fresh fruit, home-grown vegetables and fish.

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January 18, 2018 by Luke Leave a Comment

High-salt diet ups dementia risk in mice

Image result for salt diet

 Consuming high-salt diet may be harmful as it may increase the risk of dementia later in life, warns a recent study.

Researchers from Weill Cornell Medicine in New York explained that high-salt diet reduces resting blood flow to the brain and causes dementia in mice.

The study is the first to unveil a gut-brain connection, linking high dietary salt intake to neurovascular and cognitive impairment.

The findings illuminate a potential future target for countering harmful effects to the brain caused by excess salt consumption.

The researchers explained that mice fed a high-salt diet developed dementia even when blood pressure did not rise.

Researchers Senior author Dr. Costantino Iadecola, director of the Feil Family Brain and Mind Research Institute (BMRI) and the Anne Parrish Titzell Professor of Neurology at Weill Cornell Medicine.

“This was surprising since, in humans, the deleterious effects of salt on cognition were attributed to hypertension”, they added.

The mice were given food containing four percent or eight percent salt, representing an 8 to 16 fold increase in salt compared to a normal mouse diet.

The higher level was comparable to the high end of human salt consumption.

After eight weeks, the team examined the mice using magnetic resonance imaging.

The results revealed that the mice showed marked reductions in resting cerebral blood flow in two areas of the brain involved in learning and memory: 28 percent decrease in the cortex and 25 percent in the hippocampus.

The scientists discovered that an impaired ability of cells lining blood vessels, called endothelial cells, reduced the production of nitric oxide, a gas normally produced by the endothelial cells to relax blood vessels and increase blood flow.

Rodents that only ate the high-salt diet developed dementia, performing significantly worse on an object recognition test.

The research appears in Nature Neuroscience journal.

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Luke Clarke

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