Even short term administration of antibiotics (ABs) in infancy can lead to long term metabolic changes. Authors of work published in Nature’s Communications aimed to replicate the impact of the two antibiotic classes most commonly prescribed to children on the microbiome (bacteria that reside in the intestine)of mouse pups. They found that both macrolide and beta-lactam antibiotic classes produce changes in microbiota diversity that remain for months after their discontinuation. This produced long-lasting systemic metabolic consequences altering carbohydrate metabolism, liver gene expression and reducing bone density. The macrolide-based ABs had the most impact, which could suggest increased intensity of counteractive therapies such as pre- and probiotics in children prescribed these medications.
Suggest increased intensity of counteractive therapies such as pre- and probiotics in children prescribed these medications.