Luke Clarke

Functional Medicine Practitioner and Naturopath in Melbourne

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September 3, 2018 by Luke Leave a Comment

5 Ways You Might Upset Your Gut Microbiome and What to Do About It

‘Microbiome’ is a hot topic right now for anyone interested in health; but you may be wondering what exactly it is? You’ve potentially heard about the good bacteria living within your digestive system, and may have even thought about taking a probiotic to support them. Well it’s this internal community – actually encompassing a massive 38 trillion microbes (not just bacteria) – that are collectively referred to as your commensal microbiome. When healthy and balanced, your microbiome has wide-reaching health effects, such as synthesising important vitamins you need; helping to modulate and boost your immune system; assisting with waste elimination (therefore supporting healthy bowel function); and even influencing your mood.

However, your diet and lifestyle choices can negatively impact the health of your microbiome; resulting in a reduction in both the numbers and/or diversity of the organisms within your gut. Disruption to your internal microbial community can then create an environment where pathogenic (disease causing) organisms have the opportunity to grow and prosper. This state of imbalance is termed ‘dysbiosis’, and can lead to a plethora of negative health effects, including digestive complaints, nutrient deficiencies, or maybe a compromised immune system (which can lead to allergies and/or frequent illness) – these are all common outcomes when the microbiome becomes imbalanced.

The following are five of the most common diet and lifestyle factors that may negatively impact the health of your microbiome, along with some tips to help you re-establish a healthy and thriving microbial community once more.

Five ways you can upset your microbiome:

  1. Eating a low fibre diet: as your gut microbes rely on the fibre in your food for fuel, a low fibre diet leads to a reduction in the diversity of your microbiome.

    Interestingly, evidence now shows those who consume more than 30 different types of plants/vegetables each week have a much more diverse microbiome compared to those who consume 10 or fewer types of plants weekly.

  2. Alcohol intake: the consumption of alcohol can result in dysbiotic changes in your intestinal microbiome, and also triggers gastrointestinal inflammation. If you’re consuming more than one standard drink per day, your microbiome’s probably keen for you to abstain a bit more often!
  3. Unmanaged stress: when you are stressed, the release of the stress hormone cortisol, and adrenaline sensitise your body to inflammation, including gut inflammation. This disrupts the gut environment, compromising the conditions your beneficial microbes need to flourish.
  4. Leading a sedentary lifestyle: lack of exercise has also been linked to reduced microbial diversity in the gut – another reason to get moving!
  5. Antibiotic use: a round of antibiotics does lead to some loss of core commensal organisms (antibiotics are supposed to kill off bacteria however in this instance the good stuff goes too). This leaves the gut susceptible to microbiome imbalances and dysfunction. Due to this disruption, up to 10% of people experience gastrointestinal side effects from antibiotic use, referred to as antibiotic-associated diarrhoea (AAD).

Do any of these situations apply to you? Fortunately, there are a few things you can do to support your microbiome and help correct any imbalance.

Fighting, Fixing and Fuelling

Addressing the five diet and lifestyle factors listed above is important for improving the health and diversity of your microbiome. Managing your stress levels, utilising antibiotics only when specifically needed (and taking stain-specific probiotic to restore your microbiome if you do), moderating your alcohol intake, and regularly exercising will all have your microbiome singing your praises! Additionally, and perhaps most importantly, consuming a diet rich in plant based fibres will provide ample fuel for your beneficial organisms to flourish. See Table 1 below for ideas on foods your microbiome loves.

 

Table 1: Foods That Feed Your Microbiome

Nevertheless, there are situations where pathogenic organisms have the opportunity to establish within your gut and create dysbiosis, requiring specific natural formulations to address it. In this instance, antimicrobial herbal medicines can be employed, including pomegranate (Punica granatum), nigella (Nigella sativa), and myrrh (Commiphora myrrha).These herbs work to eliminate unwanted organisms within the gut, and have even shown to be as effective as their pharmaceutical counterparts in helping to reduce pathogenic populations in scientific research.

However, while eliminating pathogenic species can begin to address an imbalanced microbiome, this is only one part of the puzzle. You also need to focus on regenerating and rebuilding the diversity of your commensal microbiome, which can be achieved with specific probiotic strains such as:

    • Lactobacillus rhamnosus : one of the most studied probiotic stains in the world, research shows LGG® administration to promote the growth and function of key core commensal bacteria.
    • Saccharomyces cerevisiae (boulardii) (SB): multiple investigations have shown that boulardiireduces antibiotic-associated loss of bacteria, whilst also supporting the rapid restoration of the microbiome after antibiotic use.
    • Lactobacillus acidophilus and Bifidobacterium animalis lactis are two strains also highly indicated to protect and support a healthy microbiome.

So whilst there are factors that can upset your microbiome, be assured there is also a multitude of natural medicines, diet and lifestyle options you can harness to encourage it’s health too, and hence the wellbeing of your whole body. Many of these tips are under your control, but if you feel you need some extra help and support with antimicrobial herbs and/or strain-specific probiotics talk to your healthcare Practitioner about a tailored microbiome-restoring treatment plan to suit your needs. Your beneficial bugs will thank you for it!

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September 3, 2018 by Luke Leave a Comment

Do you know how much sugar your kids eat?

656036-zak-hemmerling-tips-sugar-out-of-fruit-loops-cereal-boxOne of my favorite shorthand ways of telling people how to eat is, “If it comes in a bag or a box, don’t eat it.”

That’s an oversimplification, of course. Some healthy foods, like eggs, do come in boxes—or cartons, at least. But as a general rule, it’s pretty safe.

Unfortunately, most Australians (especially kids) are not following this advice.

In fact, recent studies have shown that the average Australian gets 60 percent of their calories not just from processed food, but from “ultra-processed foods”—which consist of sugar, salt, fats, and oils plus artificial and natural flavors, colors, sweeteners, emulsifiers, and other additives.

One of the many reasons this is problematic is because of excess sugar intake. And this was highlighted in a recent study indicating that most parents significantly underestimate their kids’ sugar intake—primarily because of hidden sugar in processed foods that are commonly seen as “healthy.”

For example, over 90 percent of parents underestimated the amount of sugar in yogurt, by an average of seven cubes, or about 60 percent of the total amount of sugar per serving.

Perhaps not surprisingly, the misjudgments were closely correlated with the children’s body mass index (BMI). In other words, the parents with the largest underestimates of sugar content in foods had kids with the highest BMIs.

The simplest way to avoid this problem is to “just eat real food.” This means cutting out the highly processed and refined foods that have become a mainstay of the Australian diet and focusing on fresh, nutrient-dense, whole foods.

Yes, it can be a difficult transition—especially if your kids are used to eating junk.

But that’s not a reason not to do it. Many parents have gone before you, and there are plenty of resources out there now to make it easier.

With almost 20 percent of kids now obese, we urgently need to bring more attention to how they are eating. And reducing sugar consumption is probably the most important first step.

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July 30, 2018 by Luke Leave a Comment

Are You Sick of Being Sick?

 Are You Sick of Being Sick?

Are you sick of always being sick? Do you ever feel like a sitting duck waiting to be taken down by the latest pathogen doing the office rounds? Or perhaps you’ve tried to remember when the last time was you got through a whole winter season without several bouts of illness? If either of these thoughts have crossed your mind then you need to be getting some immune ‘R n R’; that is – better immune resistance and resilience.

An immune system lacking either can make you susceptible to recurrent bouts of illness. For example, if your immune system is struggling to reclaim it’s vitality after one bout of illness, then you will be susceptible to the next lot of bugs doing the rounds and hence you come down with a secondary infection. This can create the illusion that a particularly horrible virus must be on your tail. However, in this scenario, your dragging symptoms may not be entirely caused by the power of the pathogen in your system, but due to a weakened immune response, unable to resist the invader. As such, that re-appearing tickly throat or glands swelling up again can be a tell-tale sign of your immune system losing ground.

Restoring Resilience Starts With Lifestyle

No one is exempt from the many factors that can hinder your immune system – stress, lack of sleep and the inevitable balancing act of modern day life – all of which deplete our energy, hindering our degree of immune resistance and resilience. Interestingly, even your thoughts can influence your recovery time from an infection, highlighting the importance of developing a healthy mind-set. Nourishing habits to support mental wellbeing include making time to promote relaxation such as meditation, as well as light exercise; both particularly useful in reducing the immunosuppressive effects of an overactive stress response, which can simply be due to a busy life, or actual stressful events. On the other hand, ‘coping’ strategies such as consuming alcohol and smoking do the opposite – increasing your risk of infection and disease. This goes to show that positive lifestyle choices can support your road recovery, and help you break the cycle of recurrent infection.

Eating Your Way to Recovery…and Resilience

Most people are aware that eating a good diet pays dividends, but how well do you actually nourish your body during those times you feel most exhausted and fragile? You’ve potentially heard about the ‘flight and fight’ response, but did you know that the opposite of this phrase is ‘rest and digest’? Real rest is achieved by taking enough time to fully recover when you do become unwell, and acknowledging how you can best meet your needs by ensuring you are resting enough at busy times. Digest refers to the process of assimilating the nutrients from your diet, so healthy digestion is crucial to good health…and good immune function. If you have any digestive issues – speak to your healthcare Practitioner who can help investigate what’s going on.

Some foods offer significant advantages when it comes to a robust immune system. Firstly, warming foods such as crockpot stews and soups save your body time and effort breaking down raw or dense ingredients, leaving you more energy for healing if you become unwell. Secondly, consuming protein-rich foods such as eggs, legumes, nuts, and seeds ensure you have adequate nutritional resources to create new armies of immune cells, to orchestrate the destruction of a pathogenic bugs when you do come into contact with them. Finally, nutrients which are tricky to obtain, either due to low soil levels or dietary restriction, should be bolstered through supplementation where necessary – your Practitioner can help you assess if these are required. Key natural medicines, if you are lacking, ensures your body is adequately supported by the essential nutrients required to promote an active immune response and facilitate better resilience.

Natural Ingredients Have Your Back

You’ve probably heard there are certain probiotics, herbs and nutrients used to promote good health, but did you know that many of these natural ingredients actually work with your own immune system rather than just being a ‘Band-Aid’ for symptoms? For instance, nutrients such as zinc and vitamin D provide protection against infectious agents by reinforcing the strength of the immune barrier between you and the outside world, namely your gut lining. Furthermore, the immunostimulatory constituents (called polysaccharides) found in certain medicinal mushrooms including Trametes versicolor (coriolus) and Ganoderma lucidum (reishi), as well as in the herb Astragalus membranaceus(astragalus) activate several of the internal agents you need for healthy immune system surveillance and resilience (see Figure 1).

Figure 1: The Immunostimulatory Effects of Medicinal Polysaccharides.

These actions include increasing what’s known as secretory immunoglobulin A on the mucosal surface lining your gut, as well as promoting the activity of immune cells called macrophages (which translates to ‘large eaters’ giving you a picture of what they do to pathogens!) and natural killer cells, whose task is to destroy infection-causing invaders.

Taking a natural medicine approach to your health offers you so many proactive ways to improve your immune resilience in order to prevent ongoing episodes of immune dysfunction…namely illness! By addressing the underlying causes of why you keep getting sick in a holistic way, you can re-write your immune story into one which features resistance and resilience as hero’s and focus instead on enjoying all the things in life you love.

 

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July 30, 2018 by Luke Leave a Comment

Carb and Fat Combo Makes Food Extra Irresistible

Foods that have both fat and carbohydrates are more rewarding, calorie for calorie, than foods with either energy source alone, according to new research.

Fatty foods like cheese trigger one pathway of signals to reward centers in the brain while carb-loaded foods like grain or a lollipop take another route, says Dana Small, professor of psychiatry at Yale University and senior author of a new paper on the research.

“Our study shows that when the signals are combined they make foods more reinforcing,” Small says.

What makes this finding interesting, says Small, is that foods high in fat and carbohydrate do not exist in nature with only one exception: breast milk.

This makes sense, says Small, since it is important for infants to learn to suckle in order to survive.

“In the modern food environment that is rife with processed foods high in fat and carbohydrate like donuts, French fries, chocolate bars, and potato chips, this reward potentiation may backfire to promote overeating and obesity,” Small says.

Additional coauthors are from Yale and the Max Planck Institute for Metabolism Research in Germany.

The research appears in the journal

Original Study DOI: 10.1016/j.cmet.2018.05.018

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July 30, 2018 by Luke Leave a Comment

Chemicals in beef jerky and hot dogs linked to mania

 

Image result for cured meatsChemicals used to cure beef jerky, salami, hot dogs, and other processed meat snacks may contribute to mania, an abnormal mood state characterized by hyperactivity, euphoria, and insomnia, according to a new study.

The study, which appears in the journal Molecular Psychiatry, while not designed to determine cause-and-effect, did find that people hospitalized for an episode of mania were three times more likely ever to have eaten nitrate-cured meats than were people without a history of a serious psychiatric disorder. Experiments in rats by the same researchers showed mania-like hyperactivity after just a few weeks on diets with added nitrates.

When the group analyzed the gut bacteria of the rats, they found that animals with nitrate in their diet had different bacteria in their intestines than the others. The animals also had differences in several molecular pathways in the brain that have been previously implicated in bipolar disorder.

Mania, a state of elevated mood, arousal, and energy that lasts weeks to months, is generally seen in people with bipolar disorder.

While a number of genetic and other risk factors have been linked to manic episodes that characterize bipolar disorder and other psychiatric conditions, those factors have been unable to explain the cause of these illnesses. Researchers are increasingly looking for environmental factors, such as diet, that may play a role.

The new study adds to evidence that certain diets and potentially the amounts and types of bacteria in the gut may contribute to mania, the researchers say.

“Future work on this association could lead to dietary interventions to help reduce the risk of manic episodes in those who have bipolar disorder or who are otherwise vulnerable to mania,” says Robert Yolken, professor of neurovirology in pediatrics at the Johns Hopkins University.

Mania, a state of elevated mood, arousal, and energy that lasts weeks to months, is generally seen in people with bipolar disorder, but can also occur in schizoaffective disorder. Manic states can lead to dangerous risk-taking behavior and can include delusional thinking. Most of those affected experience multiple hospitalizations.

“We looked at a number of different dietary exposures and cured meat really stood out.”

Yolken, trained as an infectious disease expert, was originally interested in whether exposure to infections such as viruses transmitted through food might be linked to psychiatric conditions. He and colleagues collected demographic, health, and dietary data on 1,101 individuals with and without psychiatric disorders.

Unexpectedly, among people who had been hospitalized for mania, the team found a history of eating cured meat before hospitalization 3.5 times higher than in the group of people without psychiatric illness. Cured meats were not associated with a diagnosis of schizoaffective disorder, bipolar disorder in people not hospitalized for mania, or in major depressive disorder. No other foods had a significant association with any of the disorders.

Nitrates have long been used as preservatives in cured meat products and have been previously linked to some cancers and neurodegenerative diseases. The dietary survey did not ask about frequency or time frame of cured meat consumption, so the researchers couldn’t draw conclusions about how much cured meat may boost one’s risk of mania, but Yolken hopes future studies will address this.

To get at the roots of the association, Yolken collaborated with researchers studying the impact of nitrates on rats.

They divided otherwise healthy rats into two groups: one received normal rat chow, and the other both normal chow and a piece of store-bought, nitrate-prepared beef jerky every other day. Within two weeks, the rats eating jerky showed irregular sleeping patterns and hyperactivity.

Next, the team worked with a Baltimore beef jerky company to create a special nitrate-free dried beef. They repeated the experiment, this time giving some rats the store-bought, nitrate-prepared jerky and others the nitrate-free formulation. The animals that ate the nitrate-free meat behaved similarly to a control group, while the animals that consumed the nitrates once again showed sleep disturbances and hyperactivity similar to that seen in mania.

The results were then replicated with a specially formulated rat chow that had either nitrate added directly to the chow, or no nitrate.

The amount of nitrate consumed on a daily basis by the rats—when scaled up to the size of a human—was equivalent to the amount a person might eat for a daily snack, such as one beef jerky stick or hot dog.

“We tried to make sure the amount of nitrate used in the experiment was in the range of what people might reasonably be eating,” Yolken says.

When the group analyzed the gut bacteria of the rats, they found that animals with nitrate in their diet had different bacteria in their intestines than the others. The animals also had differences in several molecular pathways in the brain that have been previously implicated in bipolar disorder.

While occasional cured meat consumption is unlikely to spur a manic episode in most of the population, Yolken says the findings add to evidence that multiple factors contribute to mania and bipolar disorder.

Source: Johns Hopkins University

Original Study DOI: 10.1038/s41380-018-0105-6

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